Chemical identity
Every value states its source: database, literature, or calculation. Calculated values are not presented as PubChem data.
| Compound class | Modified analogue of the GHRH(1-29) fragment |
|---|---|
| Synonyms | Modified GRF (1-29) · Mod GRF 1-29 · тетразамещённый GRF(1-29) |
| Formula (with DAC) | C165H269N47O46PubChem |
| Mass (with DAC) | ≈3647.2 г/мольPubChem |
| CAS (with DAC) | 446262-90-4PubChem |
| PubChem CID (with DAC) | 91971820PubChem |
| Formula (No DAC) | C152H252N44O42calculatedCALCULATED value. Derived from the published substitution set [D-Ala2, Gln8, Ala15, Leu27]-GRF(1-29)NH2. No separate authoritative database record is relied on for this form — the value must not be read as PubChem-sourced. |
| Mass (No DAC) | ≈3367.9 г/мольcalculatedCALCULATED value derived from the sequence. The ~280-unit difference from the DAC form allows the two to be distinguished by mass spectrometry. |
| Chain length | 29 остатковliterature |
| Sequence | Tyr-D-Ala-Asp-Ala-Ile-Phe-Thr-Gln-Ser-Tyr-Arg-Lys-Val-Leu-Ala-Gln-Leu-Ser-Ala-Arg-Lys-Leu-Leu-Gln-Asp-Ile-Leu-Ser-Arg-NH2Four substitutions relative to native GRF(1-29): D-Ala at 2, Gln at 8, Ala at 15, Leu at 27; the C-terminus is amidated. The D-amino acid means mass does not confirm stereochemistry. |
The shared backbone
Both compounds are built on fragment 1-29 of growth-hormone-releasing hormone (GHRH) — the shortest segment retaining the full hormone's biological activity. In both versions it carries four amino-acid substitutions that increase resistance to enzymatic degradation, hence the literature name "tetrasubstituted GRF(1-29)".
What DAC does
DAC (Drug Affinity Complex) is a maleimidopropionic-acid-based linker that covalently couples the peptide to albumin in blood. Albumin binding protects the peptide from rapid clearance: in the clinical study by Teichman and colleagues (2006), single administrations of CJC-1295 with DAC sustained elevated growth-hormone and IGF-1 levels in healthy adults for several days.
The no-DAC version lacks the linker and is short-acting — on the scale of minutes, like GHRH itself. Substantially fewer clinical data exist for this version specifically.
Why the names are confused
Historically, "CJC-1295" was the development code for the DAC version specifically. The research-materials market later adopted "CJC-1295 without DAC" and "Modified GRF (1-29)" as interchangeable labels for the short version — usage documented in a public FDA docket. When reading literature or documentation, always check which of the two molecules is meant: their masses and pharmacokinetics differ.
Catalogue position
The Moscow Peptides catalogue item is the no-DAC version (Modified GRF 1-29). Batch identity can be confirmed only through reviewed analytical documentation; until then, identity remains pending confirmation. The material is for laboratory research only.
References
- Prolonged stimulation of growth hormone (GH) and insulin-like growth factor I secretion by CJC-1295, a long-acting analog of GH-releasing hormone, in healthy adults — Journal of Clinical Endocrinology & Metabolism (PMID 16352683), 2006.
- CJC 1295 Modified GRF (1-29) (same as CJC 1295 w/out DAC), CJC 1295 + DAC — nomenclature submission — FDA docket FDA-2024-N-4777, regulations.gov, 2024.