Chemical identity
Every value states its source: database, literature, or calculation. Calculated values are not presented as PubChem data.
| Compound class | Synthetic pentapeptide, growth hormone secretagogue |
|---|---|
| Synonyms | Ипаморелин · NNC 26-0161 |
| Molecular formula | C38H49N9O5PubChem |
| Average molecular mass | 711.9 г/мольPubChem |
| CAS | 170851-70-4PubChem |
| PubChem CID | 9831659PubChem |
| Chain length | 5 остатковliterature |
| Sequence | Aib-His-D-2-Nal-D-Phe-Lys-NH2The sequence contains non-standard residues (Aib, D-2-naphthylalanine, D-phenylalanine) and an amidated C-terminus, so it is not written in one-letter code. The D-amino acids mean a stereoisomer shares the same mass: mass spectrometry alone does not confirm stereochemistry. |
Identity
Ipamorelin is a synthetic peptide of five amino-acid residues belonging to the growth hormone secretagogue (GHS) class. It acts through the GHS receptor — the same receptor bound by ghrelin.
The key published work
The foundational characterisation was published by Raun and colleagues in the European Journal of Endocrinology in 1998, describing ipamorelin as the first selective GHS: it stimulated growth-hormone secretion in experimental models while — unlike earlier compounds of the class — leaving ACTH and cortisol levels largely unaffected.
Clinical status
Ipamorelin entered early-phase clinical studies (including post-surgical indications), but development was never completed and it is not registered as a medicine anywhere. No published data describe long-term human use.
Catalogue status
Ipamorelin in the Moscow Peptides catalogue is a research material for laboratory work. It is not intended for human use.
References
- Ipamorelin, the first selective growth hormone secretagogue — European Journal of Endocrinology, 139(5), 552–561 (PMID 9849822), 1998.