Chemical identity
Every value states its source: database, literature, or calculation. Calculated values are not presented as PubChem data.
| Compound class | Mitochondrial-derived peptide (MDP) |
|---|---|
| Synonyms | MOTS-c · mitochondrial ORF of the 12S rRNA type-c |
| Molecular formula | C101H152N28O22S2PubChem |
| Average molecular mass | 2174.6 г/мольPubChem |
| PubChem CID | 146675088PubChem |
| Chain length | 16 а.о.literature |
| Encoded by | mtDNA, ген 12S рРНК (MT-RNR1)literature |
| Sequence | MRWQEMGYIFYPRKLRFormula and average mass were independently recomputed from the sequence shown and matched the PubChem record. |
Origin and identity
MOTS-C (mitochondrial open reading frame of the 12S rRNA type-c) is a peptide encoded by a short open reading frame inside the mitochondrial 12S rRNA gene — unusual, because most peptides are encoded by the nuclear genome.
It was first described in 2015 by Lee and colleagues in Cell Metabolism, where the peptide was detected in tissues and plasma and shown to participate in metabolic regulation in animals.
What published research covers
The bulk of the evidence is preclinical: cell lines and rodents. These models describe effects on metabolic homeostasis, insulin sensitivity, and exercise adaptation, with proposed mechanisms involving the AMPK pathway and stress-induced nuclear translocation.
Human studies are few and mostly observational or pilot in nature. Drawing conclusions about effects in humans from these data would be premature.
What the literature does not contain
There are no large controlled clinical trials of MOTS-C and no approved medical use. Claims about therapeutic effects in humans go beyond the available data.
Catalogue status
MOTS-C in the Moscow Peptides catalogue is a research material for laboratory work. It is not intended for human use. Batch documentation is published once its relationship to the material is verified.
References
- The Mitochondrial-Derived Peptide MOTS-c Promotes Metabolic Homeostasis and Reduces Obesity and Insulin Resistance — Cell Metabolism, 21(3), 443–454 (PMID 25738459; DOI 10.1016/j.cmet.2015.02.009), 2015.