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What is a CAS number?

In brief

A CAS number is a unique numeric identifier for a chemical substance in the Chemical Abstracts Service registry. It names one specific structure, including salt form and hydration: a peptide base and its acetate salt have different numbers. A CAS number certifies which substance is meant — it says nothing about the quality of a given material.

Illustration for the research article

What it is

A CAS Registry Number is an identifier assigned to substances by the Chemical Abstracts Service. The format is up to ten digits in three groups, e.g. "NNNNNNN-NN-N". Numbers are unique — one structure, one number — with no chemical meaning encoded in the digits themselves.

Why one peptide can have several numbers

Different forms of a substance — free base, acetate, hydrochloride, hydrates — are separate registry entries with separate numbers. For peptides this matters constantly: commercial materials are typically supplied as salts, and the correct CAS number depends on the actual form, which manufacturer documentation must confirm.

What a CAS number does not guarantee

The number identifies the substance as a concept, not the contents of a particular vial. It confirms neither batch identity, nor purity, nor quantity. A CAS number on a product card without analytical documentation is a statement of intent, not evidence.

This is why the Moscow Peptides catalogue states a CAS number only once the material's actual form is confirmed by its documentation. Where the form is unconfirmed, the field stays empty with a "pending confirmation" status — a deliberate accuracy policy.

References

  1. Reversed-Phase High-Performance Liquid Chromatography in Peptide and Protein Analysis — Encyclopedia of Analytical Chemistry (DOI 10.1002/9780470027318.a1631), 2000.