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What is BPC-157? What the research shows

In brief

BPC-157 is a synthetic 15-amino-acid peptide related to a protein fraction of gastric juice and described in the literature as a "stable gastric pentadecapeptide". Nearly all of the evidence comes from animal experiments on gastrointestinal, tendon, and vascular healing. No controlled clinical efficacy trials in humans have been published.

Illustration for the research article

Chemical identity

Every value states its source: database, literature, or calculation. Calculated values are not presented as PubChem data.

Identification data: BPC-157
Compound classSynthetic pentadecapeptide (15 amino acid residues)
SynonymsBPC 157 · PL 14736 · Body Protection Compound 157
Molecular formulaC62H98N16O22PubChem
Average molecular mass1419.5 г/мольPubChem
CAS137525-51-0PubChem
PubChem CID9941957PubChem
Chain length15 а.о.literature
SequenceGEPPPGKPADDAGLVFormula and average mass were independently recomputed from the sequence shown and matched the PubChem record.

Identity

BPC-157 (Body Protection Compound 157) is a synthetic peptide of 15 amino-acid residues. The literature describes it as a fragment related to a gastric-juice protein and uses the term "stable gastric pentadecapeptide", reflecting the molecule's stability in the gastric environment.

What preclinical studies show

A large body of rodent work covers models of gastrointestinal, tendon, ligament, muscle, and vascular injury, describing cytoprotective effects and accelerated healing. Proposed mechanisms include modulation of the nitric-oxide system and vessel recruitment.

A notable feature of this literature is that much of it originates from a single research group; independent replication elsewhere is limited. That matters when weighing the reliability of the findings.

Human data

No randomised controlled efficacy trials of BPC-157 in humans have been published, and no regulator has approved it as a medicine. Claims of proven clinical effects do not match the current literature.

Catalogue status

BPC-157 in the Moscow Peptides catalogue is a research material for laboratory use. It is not intended for human use. Batch documentation is published after its provenance is verified.

References

  1. Stable gastric pentadecapeptide BPC 157: novel therapy in gastrointestinal tract — Current Pharmaceutical Design (PMID 21548867), 2011.
  2. Novel Cytoprotective Mediator, Stable Gastric Pentadecapeptide BPC 157. Vascular Recruitment and Gastrointestinal Tract Healing — Current Pharmaceutical Design (PMID 29879879), 2018.
  3. Stable Gastric Pentadecapeptide BPC 157 and Wound Healing — Frontiers in Pharmacology, 12, 627533 (DOI 10.3389/fphar.2021.627533), 2021.